May 9, 2018 lead candidate is the antibody CAN04, which has a dual mechanism of antibody attaches to the IL1RAP receptor molecule and blocks it from

Cantargia develops antibody-based pharmaceuticals against IL1RAP. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and

The antibody CAN04 binds IL1RAP with high affinity and functions through both An Open-label, Safety and Tolerability Phase 1b Trial of CAN04, a Fully Humanized Anti-IL1RAP Monoclonal Antibody, in Combination With Pembrolizumab in Subjects With Solid Tumors Progressing on PD-1/PD-L1 Inhibitor-containing Regimens The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling. Thereby, CAN04 can counteract the contribution of the IL-1 The basis for this is the protein IL1RAP that is involved in a number of diseases and where Cantargia has established a platform. The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1α and IL-1β signaling. CAN04 is investigated in an open label phase I/IIa clinical trial, CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP, a co-receptor for the IL-1 receptor which is expressed on human cancer cells. CAN04 binds to IL1RAP with high affinity in a manner that blocks signal transduction from IL-1 and IL-33 into the cells.

Can04 antibody

The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 The CAN04 antibody is targeted against IL1RAP, found in a number of cancer forms. The first sites in the phase I/IIa clinical trial CANFOUR have been initiated and patient recruitment is ongoing. According to the protocol, patients are recruited in groups of three.

Anti-drug antibodies (ADA) against CAN04 • Anti-Drug Antibodies (ADA) against CAN04. Preliminary signs of efficacy • Overall Response Rate (ORR) using irRC and RECIST 1.1; with irRC to be the decision-making criteria. • Duration of Response (DoR). • Progression Free Survival (PFS) at 12 months and for the duration of the trial

The CAN04 antibody is targeted against IL1RAP, found in a number of cancer forms. The first sites in the phase I/IIa clinical trial CANFOUR have been initiated and patient recruitment is ongoing.

investigating antibody CAN04 and FOLFIRINOX in pancreatic can. 2021-03-10 08:30:00 Other information disclosed according to the rules of the Exchange

Mar 9, 2021 The anti-IL-1 beta antibody is still in a couple more pivotal NSCLC studies, Can04, like canakinumab, is also being tested in combination with Nov 26, 2020 CAN10 is fully humanized monoclonal antibody targeting IL1RAP. The main project, the antibody CAN04, is being studied clinically as Aug 15, 2020 CAN04 is a fully humanized antibody that binds IL1RAP with high affinity (Kd = 1.10 pM), disrupts IL1α and IL1β signaling (IC50 = 3.9 and 4.1 nM Cantargia develops antibody based therapy against the target IL1RAP. The lead candidate CAN04 is for treatment of solid tumors and hematoligacal cancers, Feb 10, 2021 The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Rabbit mAbs were isolated using selected lymphocyte antibody method (SLAM) CAN-04-0240 pmid:http://www.ncbi.nlm.nih.gov/pubmed/15289306. Jun 16, 2020 for pre-clinical evaluation of CAN04 for lung and pancreatic cancer of a a novel antibody, CAN04, under development for this indication. investigating antibody CAN04 and FOLFIRINOX in pancreatic can. 2021-03-10 08:30:00 Other information disclosed according to the rules of the Exchange Oct 6, 2017 In this trial the antibody CAN04, directed towards the molecular target IL1RAP, will be investigated in patients with cancer.

CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC).
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CAN04 is investigated in two clinical trials. Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP). The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling.

Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy.
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The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Cytotoxicity (ADCC). Preclinical data show that CAN04 can

Mar 1, 2021 The main project, the antibody CAN04, is being studied clinically as combination therapy with chemotherapy or immune therapy with a primary Aug 23, 2019 The investigational antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of interleukin 1 signaling. Oct 8, 2013 BackgroundProtein and antibody arrays have emerged as a promising technology to study protein We applied antibody arrays to discover a panel of proteins which may serve as biomarkers to distinguish CAN-04-2033. Oct 20, 2018 The process of antibody-dependent cell-mediated cytotoxicity against [1]A First -in-Human Study of CAN04 in Patients With Solid Malignant Dec 12, 2012 ErbB/HER-targeting by monoclonal antibodies such as cetuximab and trastuzumab or tyrosine-kinase The combination of erlotinib with monoclonal antibodies represents a potential strategy to improve the CAN-04-0562. Targeted antibodies are a type of immunotherapy that can disrupt cancer cell Monoclonal Antibodies, Antibody-Drug Conjugates, and Bispecific Antibodies.

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Cantargia's lead candidate is the antibody CAN04, which has a dual mechanism of action, as it fights cancer by activating the immune system and by blocking

• New phase I clinical data on Cantargia´s antibody CAN04 (nidanilimab) were presented June 2 in an oral session at Cantargia AB: Cantargia ansöker om start av ny klinisk studie kring antikroppen CAN04 och FOLFIRINOX i bukspottkörtelcancer.